American Journal of Bioethics.

Two Watershed Stem Cell Experiments: A Look Back

As the American Journal of Bioethics publishes its centenary issue, a new—and sometimes controversial—scientific discipline has been forged from the traditions of cell biology, embryology, cancer, and genetics. Some peg the beginnings of stem cell biology to James Thomson’s 1998 experiment, when he derived human embryonic stem cells (hESCs) from a 2-day-old embryo. But like any epic advance, there are back stories. My favorite is of the German embryologist Hans Spemann, who worked with salamanders. He transferred the nucleus of a 16-cell embryo to an embryonic cell with no nucleus, and hatched a normal salamander. His was the first cloning experiment using nuclear transfer. It was 1920. [...]

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Volume 13, Issue 1
January 2013