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Author Archive: Jon Holmlund

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11/16/2017

More about gene therapy and human gene editing

To my post of last week, add the case of a 44 year-old man who has received gene therapy for an inherited metabolic disease called Hunter’s syndrome. This is another example of a form of gene editing as true therapy.  That is, an existing individual is given a construct intended to edit his genes to introduce a gene that makes an enzyme that is lacking... // Read More »

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11/10/2017

There’s gene therapy and there’s gene therapy

I’ve seen a number of different things described in the general press as “gene therapy.” But they are indeed different.  It’s important to be specific. For one, there’s the situation where a set of mature human cells are obtained from the person to be treated and genetically altered outside the body to make them into a potentially useful treatment, then re-administered (by vein) to the... // Read More »

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11/10/2017

There’s gene therapy and there’s gene therapy

I’ve seen a number of different things described in the general press as “gene therapy.” But they are indeed different.  It’s important to be specific. For one, there’s the situation where a set of mature human cells are obtained from the person to be treated and genetically altered outside the body to make them into a potentially useful treatment, then re-administered (by vein) to the... // Read More »

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10/20/2017

Regarding objections to the change in the contraceptive coverage rule

The Journal of the American Medical Association carries a “Viewpoint” piece that categorically rejects the Trump administration’s reversal of its predecessor’s mandate that employer-based health insurance include payments for contraceptives.  As reported in the general press, the current administration’s new stance was hailed by religious and other political conservatives as a welcome support of conscience rights. Read the article here.  Briefly, some key points and... // Read More »

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10/13/2017

Two cases of genetics ethics issues

There is an ongoing NIH-sponsored database effort called the Genotype-Tissue Expression (GTEx) project the goal of which is to collect data on genetics–not just DNA gene sequences, but also gene activity, looking at “expression,” which is reflected in the RNA that is transcribed from genes–in a wide range of human tissues.  The tissues are obtained from deceased voluntary organ donors.  The ethical issues are not... // Read More »

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10/06/2017

Human gene editing marches on

Nature has recently carried two new reports of human gene editing.  In one, embryos donated from an IVF clinic had a gene critical to very early development altered, to study what happens when you do that, and try to understand early human development more than we now do.  In the other, scientists studied editing of an abnormal recessive gene, specifically the one causing a type... // Read More »

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This entry was posted in Genetics, Health Care, Stem Cells and tagged , , , , , . Posted by Jon Holmlund. Bookmark the permalink.

09/07/2017

A Modest Proposal

FDA should regulate digital games, and potentially other apps, as medical devices. Why, pray tell? One doesn’t have to look very hard to find a growing belief (recognition?) that video games are addicting.  CBS has been on the story since at least 2007.  In 2014, “60 minutes” suggested that a violent video game could prompt murder.  Well, they posed it as a question, but to... // Read More »

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09/01/2017

Questioning whether genes in human embryos were in fact successfully edited

Nature reports that the editing of a gene in human embryos–reported earlier in August and discussed recently on this blog–has been questioned by a different group of scientists. Read a fuller, general-public-level description here. The questioning scientists doubt a specific claim of the initial work; namely, that a faulty gene in human sperm was edited through a corresponding gene in the human egg fertilized by... // Read More »

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08/25/2017

Fetal tissue and commerce

You may have seen in the general press that Indiana University is asking a federal judge to declare unconstitutional that state’s law banning research on the remains of aborted fetuses.  I noticed an article in the Wall Street Journal (subscription required).  An open-access account can be found here. I oppose abortion, but I can imagine for the sake of argument that, if one allows for... // Read More »

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This entry was posted in Health Care and tagged , , , , . Posted by Jon Holmlund. Bookmark the permalink.

08/25/2017

Fetal tissue and commerce

You may have seen in the general press that Indiana University is asking a federal judge to declare unconstitutional that state’s law banning research on the remains of aborted fetuses.  I noticed an article in the Wall Street Journal (subscription required).  An open-access account can be found here. I oppose abortion, but I can imagine for the sake of argument that, if one allows for... // Read More »

Full Article

This entry was posted in Health Care and tagged , , , , . Posted by Jon Holmlund. Bookmark the permalink.