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100th Issue Anniversary Editorial
David Magnus

You could say that Dolly the sheep gave birth to AJOB, that the journal issued from developing embryonic stem cells. In the late 1990s bioethics changed. While Art Caplan and some other bioethicists had appeared semiregularly in the media (particularly during periods of high controversy), cloning and stem cell research captured the public imagination like few controversies before it. Media attent...

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Two Watershed Stem Cell Experiments: A Look Back
Christopher Scott

As the American Journal of Bioethics publishes its centenary issue, a new—and sometimes controversial—scientific discipline has been forged from the traditions of cell biology, embryology, cancer, and genetics. Some peg the beginnings of stem cell biology to James Thomson’s 1998 experiment, when he derived human embryonic stem cells (hESCs) from a 2-day-old embryo. But like any epic ad...

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Target Article

The Argument from Potentiality in the Embryo Protection Debate: Finally “Depotentialized”?
Marco Stier & Bettina Schoene-Seifert

Debates on the moral status of human embryos have been highly and continuously controversial. For many, these controversies have turned into a fruitless scholastical endeavor. However, recent developments and insights in cellular biology have cast further doubt on one of the core points of dissent: the argument from potentiality. In this article we want to show in a nonscholastical way why this ar...

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Assessing ESCROs: Yesterday and Tomorrow
Henry T. Greely

The substantial public support for hES [human embryonic stem] cell research and the growing trend by many nonfederal funding agencies and state legislatures to support this field requires a set of guidelines to provide a framework for hES cell research. In the absence of the oversight that would come with unrestricted federal funding of this research, these guidelines will offer reassurance to the...

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