Vol. 14 No. 9 | September 2014

Vol. 14 No. 9 | September 2014

ISBN: 1526-5161

editorial.

The concept of minimal risk in research with children has been fraught with controversy since the pediatric regulations (45 CFR 46, Subpart D) were first adopted in 1991. The pediatric regulations allow an institutional review board (IRB) to approve Department of Health and Human Services-funded nonbeneficial research judged to have no more than minimal risk (45 CFR 46.404) or a minor increase o...

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target articles.

To protect children in research, procedures that are not administered in the medical interests of a child must be restricted. The risk threshold for these procedures is generally measured according to the concept of minimal risk. Minimal risk is often defined according to the risks of “daily life.” But it is not clear whose daily life should serve as the baseline; that is, it is not clear to w...

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Professionalism requires that physicians uphold the best interests of patients while simultaneously insuring just use of health care resources. Current articulations of these obligations like the American Board of Internal Medicine (ABIM) Foundation’s Physician Charter do not reconcile how these obligations fit together when they conflict. This is the problem of dual agency. The most common ...

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