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EDITORIAL

Don’t Blame Hippocrates for Low Enrollment in Clinical Trials
John D. Lantos

Alex John London (2021) is frustrated by the commonly encountered situation of doctors thinking that they know what is best for their patients even as they are aware that the evidence for their preferences is thin or flawed or non-existent. He thinks that such doctors should be more willing than they are now to enroll their patients in clinical trials in order to determine which treatments are saf...

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Target Article

Self-Defeating Codes of Medical Ethics and How to Fix Them: Failures in COVID-19 Response and Beyond
Alex John London

Statements of the core ethical and professional responsibilities of medical professionals are incomplete in ways that threaten fundamental goals of medicine. First, in the absence of explicit guidance for responding to cases in which there is significant uncertainty or disagreement about the relative therapeutic, prophylactic or diagnostic merits of available interventions they perpetuate self-def...

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Human Brain Surrogates Research: The Onrushing Ethical Dilemma
Henry T. Greely

Human brain research is moving into a dilemma. The best way to understand how the human brain works is to study living human brains in living human beings, but ethical and legal standards make it difficult to do powerful research with actual human beings. So neuroscientists have developed four types of surrogates for living human brains in human bodies: genetically edited non-human animals, human/...

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