Vol. 2 No. 1 | January 2011

Vol. 2 No. 1 | January 2011

ISBN: 2150-7740

target articles

Deep Brain Stimulation in Parkinsonian Patients—Ethical Evaluation of Cognitive, Affective, and Behavioral Sequelae

Sabine Müller & Markus Christen

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an important therapeutic advancement for the treatment of Parkinson’s disease (PD). Its beneficial effects on motor functions are well established, but its cognitive, affective, and behavioral sequelae come increasingly into the focus of the medical and ethical discussion. In order to evaluate whether these side effects may cou...

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Open Peer Commentary

Deep Brain Stimulation in Parkinsonian Patients—Implications for Trialing DBS in Intractable Psychiatric Disorders Wayne Hall & Adrian Carter
Subjective Outcomes Measurement and Regulatory Oversight for Deep Brain Stimulation in Parkinson's Disease Ghislaine Mathieu, Emily Bell & Eric Racine
Who Should Hold the Remote for the New Me? Cognitive, Affective, and Behavioral Side Effects of DBS and Authentic Choices Over Future Personalities Robin Mackenzie
Deep Brain Stimulation for Parkinson's Disease: A Critique of Principlism as a Framework for the Ethical Analysis of the Decision-Making Process Gabrielle N. Samuel & Caragh Brosnan
Deep Brain Stimulation, Emotions, and Decision-Making Capacity Ron Berghmans
Practical Considerations in the Ethics of Parkinsonian Deep Brain Stimulation Jordan P. Amadio & Nicholas M. Boulis
Exploring Layers of Meaning with Deep Brain Stimulation Patients Daniel R. Morrison & Mark J. Bliton

Ethical Issues in Deep Brain Stimulation Research for Treatment-Resistant Depression: Focus on Risk and Consent

Laura B. Dunn, Paul E. Holtzheimer, Jinger G. Hoop, Helen S. Mayberg, Laura Weiss Roberts & Paul S. Appelbaum

Deep brain stimulation (DBS) is currently in pivotal trials as an intervention for treatment-resistant depression (TRD). Although offering hope for TRD, DBS also provokes ethical concerns—particularly about decision-making capacity of people with depression—among bioethicists, investigators, institutional review boards, and the public. Here, we examine this critical issue of informed consent f...

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Open Peer Commentary

The Ethical Differences Between Psychiatric and Neurologic DBS: Smaller Than We Think? Matthis Synofzik & Jens Clausen
Research Consent for Deep Brain Stimulation in Treatment-Resistant Depression: Balancing Risk With Patient Expectations Nir Lipsman, Mary Pat McAndrews, Andres M. Lozano & Mark Bernstein
They Might Retain Capacities to Consent But Do They Even Care? Laura Cabrera
Including Appreciation and Voluntariness: The Other Two Elements of Decision-Making Capacity Alessandro Manduca-Barone
Desperation May Affect Autonomy but Not Informed Consent Teresa Swift