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Target Article

Deep Brain Stimulation in Parkinsonian Patients—Ethical Evaluation of Cognitive, Affective, and Behavioral Sequelae
Sabine Müller & Markus Christen

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an important therapeutic advancement for the treatment of Parkinson’s disease (PD). Its beneficial effects on motor functions are well established, but its cognitive, affective, and behavioral sequelae come increasingly into the focus of the medical and ethical discussion. In order to evaluate whether these side effects may cou...

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Ethical Issues in Deep Brain Stimulation Research for Treatment-Resistant Depression: Focus on Risk and Consent
Laura B. Dunn, Paul E. Holtzheimer, Jinger G. Hoop, Helen S. Mayberg, Laura Weiss Roberts & Paul S. Appelbaum

Deep brain stimulation (DBS) is currently in pivotal trials as an intervention for treatment-resistant depression (TRD). Although offering hope for TRD, DBS also provokes ethical concerns—particularly about decision-making capacity of people with depression—among bioethicists, investigators, institutional review boards, and the public. Here, we examine this critical issue of informed consent f...

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