How drugs intended for patients ended up in the hands of illegal users: ‘No one was doing their job’
For 10 years, the government waged a behind-the-scenes war against pharmaceutical companies that hardly anyone knows: wholesale distributors of prescription narcotics that ship drugs from manufacturers to consumers.
Digital gizmos can monitor your heart, whether it’s a wrist-worn fitness tracker or a smartphone app to help cardiologists analyze diagnostic tests. The question is whether they’re going to do your heart any good. The short answer: It depends.
If your heart is going to stop, right outside a hospital is not a bad place for it. And if 41 people within a 330-yard radius have a cellphone app alerting them to your distress, so much the better.
For a long time, Daniel Au Valencia got the message that she was wrong, wrong, wrong. She stood wrong. She talked wrong. She looked at people wrong. “There’s a lot of shame around autism,” she says. “There’s a lot of being told you look weird.”
Prior to the development of iPSCs, stem cells were derived primarily from eggs fertilized in clinics in vitro that were donated for research purposes. To some, such as President George W. Bush, this was tantamount to abortion. In 2001 he banned federal funding for research on newly created human embryonic stem cell lines. (President Barack Obama lifted that ban in 2009.)
The researchers analyzed data on 74,645 adults, most in their late 50s or early 60s when the study began. None had a history of cardiovascular disease or cancer. Over a 16-year period, 17,909 of the participants died. The more processed and unprocessed red meat people ate regularly, the more likely they were to have died — 21 percent more likely than those who ate the least meat overall. Early death from a cardiovascular cause was 29 percent more likely among those whose regular diets included the most red meat compared with those who ate the least. Those risks did not change, regardless of whether people regularly ate a low, medium or high amount of fruits and vegetables. The researchers reported finding “no interaction” between red meat and fruit and vegetable consumption.
Stephanie, a college student without health insurance, visited her local Planned Parenthood for a check-up she could afford. Imagine her surprise and fright when told her Pap test results were abnormal. With empathy and compassion Planned Parenthood staff guided Stephanie through a biopsy and a screening that proved her to be cancer-free.
In a tour de force of reproductive biology, scientists in Japan have transformed mouse skin cells into eggs in a dish, and used those eggs to birth fertile pups. The report marks the first creation of eggs entirely outside a mouse. If the process could be made to work for humans, researchers could produce artificial eggs without needing to implant immature cells into ovaries to complete their development.
Cancer patients taking high doses of opioid painkillers are often afflicted by a new discomfort: constipation. Researcher Jonathan Moss thought he could help, but no drug company was interested in his ideas for relieving suffering among the dying.
Last year, Bob Nore, a Vietnam War veteran in Huntsville, Ala., was working on a family tree and wanted to trace his ancestors’ history and origins. So he sent a vial of saliva and $89 to a DNA registry for analysis.
The Institute of Medicine recently highlighted that physician diagnostic error is common and information technology may be part of the solution.1 Given advancements in computer science, computers may be able to independently make accurate clinical diagnoses.2 While studies have compared computer vs physician performance for reading electrocardiograms,3 the diagnostic accuracy of computers vs physicians remains unknown. To fill this gap in knowledge, we compared the diagnostic accuracy of physicians with computer algorithms called symptom checkers.
Doctors are much better than symptom-checker programs at reaching a correct diagnosis, though the humans are not perfect and might benefit from using algorithms to supplement their skills, a small study suggests.
One of Theranos Inc.’s biggest financial backers has sued the embattled startup and its founder for allegedly lying to attract its nearly $100 million investment, according to a fund document and people familiar with the matter.
I work in Boston’s Longwood Medical Area, one of the densest concentrations of hospitals in the country, and I often have this reaction when I’m out on the street among my work neighbors: “Dude. Ew.”
Just over 80% of clinical trial data submitted to support new drug registrations in China have been revealed as fraudulent or substandard by the country’s drug regulator. An investigation of data for 1622 new drugs submitted to China’s State Food and Drug Administration (CFDA) for registration said that 1308 of the applications should be withdrawn because they contained fabricated, flawed, or inadequate data from clinical trials.
Most of us have been tempted at one time or another by the lure of sugar. Think of all the cakes and cookies you consume between Thanksgiving and Christmastime!
By the time 8-year-old Ava Christianson got to the National Institutes of Health this summer, she had lost several grueling rounds to leukemia and was bracing for the next one.
How bad is that thrice-weekly pot habit? How dangerous is it to keep a gun in your home? A new study by Eitan D. Hersh and Matthew N. Goldenberg of Yale University suggests doctors’ responses to those and other hot-button issues could be colored by their political views.
Louis Casanova is playing cards with a friend on the back deck of a recovery house in Philadelphia’s northern suburbs.
A Swedish medical researcher has taken another step toward eventually being able to engineer a custom-made human being. The experiment, first reported on NPR Thursday involves editing the genes of a developing human embryo.
Public anger over the cost of drugs has burned hot for a year, coursing through social media, popping up on the presidential campaign, and erupting in a series of congressional hearings, including one last week over the rising price of the allergy treatment EpiPen.
Governments will begin final negotiations this week on a plan to curb carbon emissions from international aircraft flights beginning in 2020.
Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices
Depression, stress and diet can all alter inflammation. This double-blind, randomized crossover study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on inflammatory responses to high-fat meals. During two separate 9.5 h admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar controls), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. The Daily Inventory of Stressful Events assessed prior day stressors and the Structured Clinical Interview for DSM-IV evaluated MDD. As expected, for a woman with no prior day stressors, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were higher following the saturated fat meal than the high oleic sunflower oil meal after controlling for pre-meal measures, age, trunk fat and physical activity. But if a woman had prior day stressors, these meal-related differences disappeared—because the stressors heightened CRP, SAA, sICAM-1 and sVCAM-1 responses to the sunflower oil meal, making it look more like the responses to the saturated fat meal. In addition, women with an MDD history had higher post-meal blood pressure responses than those without a similar history. These data show how recent stressors and an MDD history can reverberate through metabolic alterations, promoting inflammatory and atherogenic responses.
The world’s first baby to be born from a new procedure that combines the DNA of three people appears to be healthy, according to doctors in the US who oversaw the treatment.
You must lose weight, a doctor told Sarah Bramblette, advising a 1,200-calorie-a-day diet. But Ms. Bramblette had a basic question: How much do I weigh?
TYLER, Ala. — The hard clay soil in this rural Southern county has twice cursed Dorothy Rudolph. It is good for growing cotton and cucumbers, the crops she worked as a child and hated. And it is bad for burying things — in particular, septic tanks.
The woman on the other end of the phone spoke lightheartedly of spring and of her 81st birthday the previous week. “Who did you celebrate with, Beryl?” asked Alison, whose job was to offer a kind ear. “No one, I…” And with that, Beryl’s cheer turned to despair.