Hot Topics: Genetics
The New England Journal of Medicine carries a brief article about “Controlling CRISPR-Cas9 Gene Editing” (subscription required). The upshot: RNA used as a medicine, as in the case of “CRISPR” to edit genes, can hang around well after administration, and alter genes other than the ones intended to be altered. These “off-target” effects could lead …Full Article
by Julian Savulescu, Ph.D., MBBS
… Full Article
“Life’s but a walking shadow, a poor player, that struts and frets his hour upon the stage, and then is heard no more; it is a tale told by an idiot, full of sound and fury, signifying nothing” (Macbeth, Act 5, Scene 5).
This blog has carried several comments about the prospect of heritable human gene editing. While nearly no one currently supports bringing such babies to birth—and condemns those who would rush ahead to do so—it appears a distinct minority think that we the human race should, if we could, agree never to do such a thing. …Full Article
A Guest Post Written by Jonny Anomaly It’s been 20 years since Allen Buchanan and his colleagues published From Chance to Choice: Genetics and Justice. The book was a landmark, and it repays careful reading. But there is at least one kind of question that has been largely (if not entirely) ignored in discussions […]Full Article
It is reported this week that a Russian scientist plans to edit the genes of more human embryos intending to bring gene-edited babies to birth. As with the case in China last year, the intent is to edit a gene called CCR5 that is responsible for a receptor that facilitates initiation of HIV infection. The …Full Article
You may have seen in the general press that the gene-edited twin girls born in China last year may have had their life expectancies shortened in the bargain. The doctor who edited the babies’ genes specifically edited one gene, that is associated with susceptibility to HIV infection. Their father is HIV positive, but that does …Full Article
The Editorial Board of The Washington Post (WaPo) recently published their opinion on regulation of heritable genetic changes in human eggs, sperm, and embryos. The authors expressed some measure of relief that organizations such as the National Academies in the U.S., the Royal Society in Britain, and the World Health Organization are beginning to consider …Full Article
Recently, it was reported that the panel convened by the World Health Organization (WHO) to develop standards and guidelines for gene editing will ask the WHO to establish a registry for any projects on heritable human gene editing. The idea is that, to get research funding, a project would have to be registered, and there …Full Article
Guest Post: Torbjörn Tännsjö, Kristian Claëson Emeritus Professor of Practical Philosophy Statistically speaking, women perform less well than men in most sports. Their top results are 10-12 % worse than those of men. If they are to have a chance to compete at the top level, they need a protected space. At least, this has been […]Full Article
by Keisha Ray, Ph.D.
Since 2009 Caster Semenya has been the face of hyperandrogenism in women’s sports and today her case is back in the headlines.…Full Article
Rational Freedom and Six Mistakes of a Bioconservative
Yesterday’s Child: How Gene Editing for Enhancement Will Produce Obsolescence—and Why It Matters
A Cross-Cultural Neuroethics View on the Language of Disability
The DNA Test Results That Uncovered a Family Secret
Should Researchers Offer Results to Family Members of Cancer Biobank Participants? A Mixed-Methods Study of Proband and Family Preferences
What to Expect When Expecting CRISPR Baby Number Four
Ethical Guidelines for DNA Testing in Migrant Family Reunification
“I want us to be a normal family”: Toward an understanding of the functions of anonymity among U.S. oocyte donors and recipients
A content analysis of the views of genetics professionals on race, ancestry, and genetics
Genes wide open: Data sharing and the social gradient of genomic privacy
An Ohio family using a home DNA test found that their 25-year-old daughter is not related to her father, according to a lawsuit they filed against a hospital and two fertility practices.
Joe Cartellone said his family made the discovery earlier this year after buying an Ancestry DNA kit to learn more about their Italian heritage, the family’s lawsuit filed Wednesday in the Hamilton County Court of Common Pleas said.Full Article
Dr. Craig Sweet’s fertility clinic in Fort Myers, Florida, has resulted in nearly 3,000 pregnancies.
The pregnancies, he said, have been the upside to his 28 years in the business of helping patients fulfill their dreams of having babies.
But there’s a downside: Hundreds of embryos sit in a frozen state of limbo, abandoned in the center’s storage tanks by in vitro fertilization patients who once sought the help of Sweet’s team in their journey to become parents, then walked away.
“We were not prepared for any of this,” Sweet said.Full Article
A Russian scientist says he wants to create more genetically modified babies, flouting international objections that such a step would be premature, unethical and irresponsible.Full Article
A statement from the American College of Medical Genetics and Genomics (ACMG) regarding the interpretation of genomic test results was published in Nature this weekFull Article
The price set by the Swiss drugmaker Novartis may be the world’s highest for a single treatment — prompting renewed debate about how society will pay for gene-therapy breakthroughs.Full Article
Genetic and molecular analysis of 109 volunteers turned up hidden health problems in about half of them. Critics say the approach amounted to ‘carpet-bombing’ the body.Full Article
A new experiment has raised medical and ethical questions as serious as those surrounding human gene editing: A support system delivering artificial blood to pig brains prevented degradation of important neural functions, Yale researchers discovered.