Hot Topics: Genetics

Blog Posts (91)

December 28, 2016

Modern Pregnancies and (Im)Perfect Babies

by Stephanie A. Kraft, JD

The modern experience of pregnancy is distinctly “not your mother’s pregnancy”. Ever-expanding options for carrier, prenatal, and newborn screening offer today’s pregnant women countless choices when it comes to genetic testing—choices that were unheard of, even unfathomable, just a generation ago.…

December 11, 2016

The 14-day rule: Time to double down?

The “world’s leading scientists” gathered at University College London on 7 December 2016 to explore extending the 14-day limit on embryo experimentation from 14 days to 28 days. Presently the consensus of that meeting is not known. The Guardian has published a nice summary of the background and future implications of the issue (link HERE). Jon Holmlund offered his comments in this blog back in... // Read More »
December 1, 2016

“3-Parent Babies” Sally Forth

The journal Nature reports that scientists advising the U.K.’s Human Fertilization and Embryology Authority (HEFA) have judged that attempts to bring so-called “3-parent babies” to birth is “ready for limited clinical testing.”   Presumably this means that the underlying technology, mitochondrial replacement, has been tested enough in the laboratory that it’s ready to try for human procreation.  Also presumably, HEFA will promulgate rules or guidelines to... // Read More »
November 25, 2016

Gattaca validated

In the made-for-bioethics movie Gattaca, when the main character Vincent is born, a nurse in the delivery room draws a drop of his blood, places it in the nifty instant genetic analyzer, and intones, “Heart disorder: 99% probability. Early fatal potential: life expectancy 30.2 years.” (Spoiler alert!) However, Vincent doesn’t let this genetic version of a horoscope control his life, but goes on to beat... // Read More »
November 9, 2016

Bioethics faces a rocky but navigable road

by Arthur Caplan, Ph.D.

Academic bioethics has never been popular with Republicans.  Libertarians dislike academic bioethics because it seems too elitist and anti-free market. …

October 7, 2016

More on Gene Editing

One version of the headline of a news item in Nature this week is, “UK bioethicists eye designer babies and CRISPR cows.” The UK’s Nuffield Council on Bioethics has just released a report, “Genome editing: an ethical review.”  The full report and a short summary are available for download here. I must say that my understanding of recent bioethical reflection in the UK leads me... // Read More »
September 30, 2016

Ethics & Society Newsfeed: September 30, 2016

Technology and Ethics Tech Giants Team Up To Tackle The Ethics Of Artificial Intelligence The Partnership on Artificial Intelligence to Benefit People and Society, consisting of Amazon, Facebook, Google, Microsoft and IBM (with Apple in talks to join), weighs in on the … Continue reading
September 29, 2016

Does Mitochondrial Transfer Really Save Lives?

This blog has discussed Mitochondrial Transfer, also referred to as Mitochondrial Replacement Techniques (MRTs), several times in the past (HERE and HERE to link a few.). The reason for further comment is that Dr. John Zhang, a New York-based fertility specialist admitted that he assisted in the successful fertilization and healthy delivery of a now 5 month old baby boy using the technique of Mitochondrial... // Read More »
September 25, 2016

Zika and Genetically Modified Mosquitoes

Just last week, I received a call from a pollster.  It’s election season and I live in a hotly contested ‘swing state,’ so I wasn’t surprised.   What surprised me were the questions I was asked, mostly about the Zika virus—its spread and possible prevention.  One question especially caught my attention:  Are you in favor of genetically modified (GM) mosquitos?   Bioethics in a poll question!  I... // Read More »
August 26, 2016

Public discussions on human gene editing

On August 3, the National Academies of Science, Engineering, and Medicine posted online the slides and talks from its July 12 meeting to discuss public implications of the Human Gene-Editing Initiative.  A total of four meetings plus a related workshop were held: an introductory discussion in December 2015, followed by three more substantial meetings plus the related workshop in February, April, and now July of... // Read More »

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Published Articles (56)

American Journal of Bioethics: Volume 17 Issue 1 - Jan 2017

A Framework for Unrestricted Prenatal Whole-Genome Sequencing: Respecting and Enhancing the Autonomy of Prospective Parents Stephanie C. Chen & David T. Wasserman

American Journal of Bioethics: Volume 17 Issue 1 - Jan 2017

Modern Pregnancies and (Im)Perfect Babies Stephanie A. Kraft

American Journal of Bioethics: Volume 16 Issue 12 - Dec 2016

Does Lack of “Genetic-Relative Family Health History” Represent a Potentially Avoidable Health Disparity for Adoptees? Thomas May, Kimberly A. Strong, Kaija L. Zusevics, Jessica Jeruzal, Michael H. Farrell, Alison LaPean Kirschner, Arthur R. Derse, James P. Evans & Harold D. Grotevant

AJOB Primary Research: Volume 7 Issue 3 - Jul 2016

Concerns about genetic testing for schizophrenia among young adults at clinical high risk for psychosis Ryan E. Lawrence, Phoebe Friesen, Gary Brucato, Ragy R. Girgis & Lisa Dixon

AJOB Primary Research: Volume 7 Issue 3 - Jul 2016

Clarifying ethical responsibilities in pediatric biobanking Merle Spriggs & Craig L. Fry

AJOB Primary Research: Volume 7 Issue 3 - Jul 2016

Lay attitudes toward trust, uncertainty, and the return of pediatric research results in biobanking John Lynch, Janelle Hines, Sarah Theodore & Monica Mitchell

American Journal of Bioethics: Volume 15 Issue 12 - Dec 2015

Germline Manipulation and Our Future Worlds John Harris

American Journal of Bioethics: Volume 15 Issue 12 - Dec 2015

Human Germline CRISPR-Cas Modification: Toward a Regulatory Framework Niklaus H. Evitt, Shamik Mascharak & Russ B. Altman

American Journal of Bioethics: Volume 15 Issue 12 - Dec 2015

Engineering Values Into Genetic Engineering: A Proposed Analytic Framework for Scientific Social Responsibility Pamela L. Sankar & Mildred K. Cho

American Journal of Bioethics: Volume 15 Issue 12 - Dec 2015

CRISPR Critters and CRISPR Cracks R. Alta Charo & Henry T. Greely

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News (870)

December 5, 2016 9:00 am

UK moves closer to allowing ‘three-parent’ babies (Nature)

United Kingdom may soon become the first country to explicitly permit the birth of children from embryos modified to contain three people’s DNA.

November 28, 2016 6:00 am

Climbing the social ladder can strengthen your immune system, monkey study suggests (Science)

Immune cells from low-ranking monkeys were less effective at fighting the infection.

November 17, 2016 9:00 am

CRISPR gene-editing tested in a person for the first time (Nature)

A Chinese group has become the first to inject a person with cells that contain genes edited using the revolutionary CRISPR–Cas9 technique.

October 31, 2016 8:00 am

The controversial DNA search that helped nab the 'Grim Sleeper' is winning over skeptics (LA Times)

The “Roaming Rapist” is one of a handful of cases that California authorities have quietly solved in recent years using a controversial technique that scours an offender DNA database for a father, son or brother of an elusive crime suspect.

October 25, 2016 8:00 am

Can Ecstasy Help Relieve Social Anxiety Epidemic Among Autistic People? (NPR)

For a long time, Daniel Au Valencia got the message that she was wrong, wrong, wrong. She stood wrong. She talked wrong. She looked at people wrong. “There’s a lot of shame around autism,” she says. “There’s a lot of being told you look weird.”

October 25, 2016 8:00 am

What Stem Cell Researchers Talk About When They Talk About Ethics (NPR)

Prior to the development of iPSCs, stem cells were derived primarily from eggs fertilized in clinics in vitro that were donated for research purposes. To some, such as President George W. Bush, this was tantamount to abortion. In 2001 he banned federal funding for research on newly created human embryonic stem cell lines. (President Barack Obama lifted that ban in 2009.)

October 18, 2016 8:00 am

DNA’s new ‘miracle’: How adoptees are using online registries to find their blood relatives (Washington Post)

Last year, Bob Nore, a Vietnam War veteran in Huntsville, Ala., was working on a family tree and wanted to trace his ancestors’ history and origins. So he sent a vial of saliva and $89 to a DNA registry for analysis.

October 13, 2016 8:00 am

Major Investor Sues Theranos (WSJ)

One of Theranos Inc.’s biggest financial backers has sued the embattled startup and its founder for allegedly lying to attract its nearly $100 million investment, according to a fund document and people familiar with the matter.

October 7, 2016 8:00 am

This 8-year-old is free of cancer — for now — after a ‘breakthrough’ treatment (Washington Post)

By the time 8-year-old Ava Christianson got to the National Institutes of Health this summer, she had lost several grueling rounds to leukemia and was bracing for the next one.

October 4, 2016 8:00 am

Are Swedish Designer Babies Coming Soon? (Seeker)

A Swedish medical researcher has taken another step toward eventually being able to engineer a custom-made human being. The experiment, first reported on NPR Thursday involves editing the genes of a developing human embryo.

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