October 19, 2016 8:00 am
Cancer patients taking high doses of opioid painkillers are often afflicted by a new discomfort: constipation. Researcher Jonathan Moss thought he could help, but no drug company was interested in his ideas for relieving suffering among the dying.
October 5, 2016 8:00 am
Louis Casanova is playing cards with a friend on the back deck of a recovery house in Philadelphia’s northern suburbs.
October 3, 2016 8:00 am
Public anger over the cost of drugs has burned hot for a year, coursing through social media, popping up on the presidential campaign, and erupting in a series of congressional hearings, including one last week over the rising price of the allergy treatment EpiPen.
September 29, 2016 8:00 am
Depression, stress and diet can all alter inflammation. This double-blind, randomized crossover study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on inflammatory responses to high-fat meals. During two separate 9.5 h admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar controls), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. The Daily Inventory of Stressful Events assessed prior day stressors and the Structured Clinical Interview for DSM-IV evaluated MDD. As expected, for a woman with no prior day stressors, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were higher following the saturated fat meal than the high oleic sunflower oil meal after controlling for pre-meal measures, age, trunk fat and physical activity. But if a woman had prior day stressors, these meal-related differences disappeared—because the stressors heightened CRP, SAA, sICAM-1 and sVCAM-1 responses to the sunflower oil meal, making it look more like the responses to the saturated fat meal. In addition, women with an MDD history had higher post-meal blood pressure responses than those without a similar history. These data show how recent stressors and an MDD history can reverberate through metabolic alterations, promoting inflammatory and atherogenic responses.
September 26, 2016 5:48 pm
TYLER, Ala. — The hard clay soil in this rural Southern county has twice cursed Dorothy Rudolph. It is good for growing cotton and cucumbers, the crops she worked as a child and hated. And it is bad for burying things — in particular, septic tanks.
September 23, 2016 8:00 am
The woman on the other end of the phone spoke lightheartedly of spring and of her 81st birthday the previous week. “Who did you celebrate with, Beryl?” asked Alison, whose job was to offer a kind ear. “No one, I…” And with that, Beryl’s cheer turned to despair.
August 24, 2016 8:10 am
Nearly 27 percent of the people in the country are 65 or older. NPR’s Ina Jaffe visited Japan and tells Rachel Martin what she learned about why the population is aging.
August 22, 2016 8:00 am
The Justice Department plans to end its use of private prisons after officials concluded the facilities are both less safe and less effective at providing correctional services than those run by the government.
July 25, 2016 5:04 am
When you’re pregnant, going to the doctors can be exciting. You get to find out if you’re having a boy or a girl. Maybe hear the baby’s heart beat. But in southern Africa, many women find out something else.
July 19, 2016 8:26 am
Watching a person die from cardiac arrest in an intensive care unit is devastating. It’s especially so when the person is a woman in her 40s who has been smothered to death by her own weight — and we doctors can do nothing to save her.