» Research Ethics Where the World Finds Bioethics Wed, 02 Sep 2015 17:46:38 +0000 en-US hourly 1 Hashtag Advocacy or Slacktivism: How Should We Evaluate the Impact of Social Media Campaigns for Public Health? Mon, 31 Aug 2015 12:00:25 +0000 by Macey L. Henderson, J.D.

It takes more than a TV news story or a Twitter hashtag campaign to save lives. Last August’s viral ice bucket challenge did more than just improve public health awareness of an issue. Its now been reported to have made a real impact into research for a rare disease, not just for improved public education and awareness.

An estimated 5,000 persons receive a diagnosis of Amyotrophic Lateral Sclerosis (ALS) each year in the United States, with an estimated prevalence of 12,000 cases according to the Centers for Disease Control and Prevention (CDC).…

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Reproducibility Project or Research Police? Tue, 25 Aug 2015 04:08:24 +0000 0 Ben Carson Conducted Research on Fetal Tissue — And Defends It Fri, 14 Aug 2015 17:53:23 +0000 0 Evolving Challenges and Research-Needs Concerning Ebola Thu, 13 Aug 2015 17:57:41 +0000 0 Children and Clinical Research: Ethical Issues Wed, 12 Aug 2015 17:53:30 +0000 0 The Stanford Prison Experiment film: An Essential Teaching Tool Tue, 04 Aug 2015 11:00:11 +0000 By Craig Klugman, Ph.D.

In teaching research ethics, there are a few “classic cases” that we offer students as examples of where human subject research went wrong: Tuskegee Study of Untreated Syphilis, the Nazi medical experiments, Willowbrook Hepatitis Experiments, human radiation experiments, and (now) the Guatemala syphilis study, among others. When discussing social science examples, the two studies that are usually taught at Milgram’s obedience studies and Zimbardo’s Stanford Prison Experiment.

As an undergraduate at Stanford, my Psychology 101 teacher was Philip Zimbardo.…

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Investigating Two Claims Against Planned Parenthood: Center of Medical Progress’s Secret Videos Mon, 27 Jul 2015 22:00:39 +0000 by Craig Klugman, Ph.D.

Before you being reading, I have a disclaimer: Growing up, my mother worked for Planned Parenthood. As a nurse, she practiced in their clinics offering well women services, counseling, and contraception. After many years, she went on to direct their clinic’s in vitro fertilization program. I also heard the word “Planned Parenthood” stated with a quick northeastern accent. Said that way, as a child, I thought the place was called “Plant Parenthood” and wondered what plants had to do with women’s health.…

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Video of Planned Parenthood executive discussing tissue, organ prices sparks abortion firestorm Fri, 17 Jul 2015 23:53:07 +0000 0 On the Origins of Research Ethics: China and the West Thu, 16 Jul 2015 07:23:16 +0000 by Craig Klugman, Ph.D

When I was a graduate student, I was fortunate to be one of five students chosen by the China Medical Board to attend an international bioethics conference between the U.S. and China in Beijing. We listened to talks on the philosophical bases of ethics in each country and culture. The U.S. laid its philosophical history on the doorsteps of the ancient Greek traditions such as Plato and Aristotle as well as later European thinkers such as Kant, Mill, and Bentham.…

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Can Bioethics Panels Fix the Problems With the Availability of “Compassionate Use” Experimental Drugs? Thu, 04 Jun 2015 02:06:47 +0000 0 Cost of Compassionate Use is Simply Too High Fri, 08 May 2015 21:01:23 +0000 by Craig Klugman, Ph.D.

Johnson & Johnson’s Janssen Pharmaceutical Company announced that it has contracted with New York University’s Division of Medical Ethics to assemble an external Compassionate-Use Advisory Committee (CompAC) to examine requests for investigational new drugs (INDs) outside of clinical trials. Arthur Caplan will lead this group, which will be composed of bioethicists, physicians, and patient advocates. The goal of this group is to provide recommendations on which patients should be given compassionate use access to experimental drugs.…

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Use of Unproven Interventions is Never Obligatory Fri, 08 May 2015 08:05:30 +0000 0 Withholding results from clinical trials is unethical, says WHO Thu, 30 Apr 2015 22:31:17 +0000 0 Designer Embryos: The Future is Now Thu, 23 Apr 2015 07:30:13 +0000 by Craig Klugman, Ph.D.

Oh, wonder!
How many goodly creatures are there here!
How beauteous mankind is! O brave new world,
That has such people in ’t! (Shakespeare, The Tempest, Act 5, Scene 1.

Nature News on Wednesday reported a group of Chinese researchers have successful genetically engineered a human embryo.

Researchers used “non-viable” embryos from fertility clinics. These embryos had an extra set of chromosome, having been fertilized by two sperm and containing three nuclei. Such embryos were chosen because of the impossibility of them gestating into a human being.…

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Are religious research subjects a vulnerable population? Wed, 15 Apr 2015 19:28:11 +0000 by Craig Klugman, Ph.D.

A recent study in the journal Psychology Science found that when people are thinking about God, they are more likely to state a willingness to participate in nonmoral,° risky behaviors such as skydiving, substance abuse, and speeding. To reach their conclusion, the researchers asked online participants to undertake a short writing task. Half of the participants were asked to incorporate words that reminded them of God and half did not.

The participants then took one of several scenario tests where they were asked their willingness to participate in risky behaviors.…

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Examining the Ethics of Clinical Use of Unproven Interventions Outside of Clinical Trials During the Ebola Epidemic Wed, 01 Apr 2015 20:12:44 +0000 0 Selecting the Right Tool For the Job Wed, 01 Apr 2015 20:11:06 +0000 0 Grants help level the playing field for young moms in science Mon, 30 Mar 2015 22:57:03 +0000 0 Research 2.0: Rise of the Citizen-Scientist and the Death of Privacy Thu, 26 Mar 2015 07:34:05 +0000 by Craig Klugman, Ph.D.

On Monday I attended a symposium on inter-professional education. During a session on new technologies in medicine (telemedicine, wearables, and mobile devices) I brought up the question of preserving privacy. The foundation sponsoring the event replied to me, “There is no such thing as privacy. It’s dead.” For someone who works in bioethics, serves on an IRB, and was formerly a journalist, this notion is scary. Perhaps, I have simply been in denial. After all, I use a mobile phone that tracks my position, synchs with the cloud, and provides much convenience.…

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Build it (an easy way to join research studies) and the volunteers will come Wed, 18 Mar 2015 17:49:56 +0000 0 Apple’s ResearchKit to give scientists ready access to study subjects Mon, 09 Mar 2015 22:26:40 +0000 0 The Social Determinants of Health: Why Should We Care? Sun, 01 Mar 2015 19:40:41 +0000 0 Precision Medicine Has Imprecise Ethics Wed, 18 Feb 2015 06:59:03 +0000 by Craig Klugman, Ph.D.

How do physicians diagnose disease? First they go through a set of symptoms and then compile a list of differential diagnoses or what the underlying disease may be. Then the doctor performs tests to rule out some diagnoses and advance others. In essence, though, diseases are classified according to their affect on the body—their symptology. What if instead of by symptoms, diseases were classified by their molecular function? Instead of being diagnosed with Type II Diabetes one might be diagnosed by whether there is a death of beta cells (i.e.…

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The new scientific revolution: Reproducibility at last Mon, 02 Feb 2015 19:49:36 +0000 0 “Post Publication peer review: Promise or Chaos?” Revisited Mon, 12 Jan 2015 05:01:18 +0000 0 Shared Vulnerabilities in Research Mon, 01 Dec 2014 21:05:15 +0000 0 Scientific Research: Critiquing the Critics Wed, 26 Nov 2014 10:11:04 +0000 0 Wed, 19 Nov 2014 21:35:21 +0000 0 Human-subjects research: The ethics squad Tue, 04 Nov 2014 20:50:53 +0000 0 White House to Cut Funding for Risky Biological Study Mon, 03 Nov 2014 20:43:06 +0000 0 Does Your Average Scientist Need an Ethicist on Call? Mon, 03 Nov 2014 20:27:21 +0000 0 Is it Ethical to give Ebola-Sufferers a Placebo? Mon, 03 Nov 2014 03:11:34 +0000 0 “You Don’t Know Me, But …”: Access to Patient Data and Subject Recruitment in Human Subjects Research Sat, 01 Nov 2014 21:15:47 +0000 0 Ethical Justifications for Access to Unapproved Medical Interventions: An Argument for (Limited) Patient Obligations Sat, 01 Nov 2014 20:46:34 +0000 0 Compassion and Research in Compassionate Use Sat, 01 Nov 2014 20:42:40 +0000 0 The Ethics of Experimenting on Yourself Tue, 28 Oct 2014 17:43:00 +0000 0 Case Study: Ethical Implications of Social Media in Health Care Research Wed, 01 Oct 2014 18:29:32 +0000 0 Case Study Introduction: Challenging Cases in Research Ethics Wed, 01 Oct 2014 18:25:46 +0000 0 Videos explain concepts of clinical research Tue, 30 Sep 2014 18:27:31 +0000 0 U.S. agency moves to end sex bias in biomedical research Tue, 23 Sep 2014 17:54:11 +0000 0 NIH issues finalized policy on genomic data sharing Wed, 10 Sep 2014 18:49:21 +0000 0 On the Minimal Risk Threshold in Research With Children Mon, 01 Sep 2014 18:34:50 +0000 0 Making Sense of the Undue Burden Interpretation of Minimal Risk Mon, 01 Sep 2014 18:32:56 +0000 0 Japan scientist in discredited stem-cell research dead in suicide Tue, 12 Aug 2014 17:58:41 +0000 0 Scientists retract narcolepsy study linked to GSK vaccine Mon, 11 Aug 2014 17:56:45 +0000 0 Ethical questions emerge over who gets Ebola drug Mon, 11 Aug 2014 17:31:21 +0000 0 Ebola Outbreak Highlights Questions about Experimental Drug Treatment Fri, 08 Aug 2014 08:08:18 +0000 0 The Ethics of Ebola and Scarce and Experimental Drugs Thu, 07 Aug 2014 04:08:27 +0000 by: J.S. Blumenthal-Barby

Yesterday I was contacted by the L.A. Times to answer a simple question: Should we give people access to the experimental Ebola drug, ZMapp?

The Drug and Clinical Trial Phases
So, I did a little digging to try to find out some more details about the drug. From what I could find in published news reports, the drug was developed by Mapp Biopharmaceutical Inc., with support from the NIH and the Defense Threat Reduction Agency. It has been tested on 8 monkeys.…

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Do OkCupid and Facebook experiment on vulnerable populations? Mon, 04 Aug 2014 18:25:10 +0000 by Keisha Ray, Ph.D.

A few months ago Facebook announced that some Facebook users were a part of a 2012 experiment. In the experiment Facebook altered the number of negative and positive posts and photos that appeared in users’ newsfeed. In a paper documenting the results of the study, authors noted that by changing what users saw in their feed, Facebook was able to alter moods, emotions, and the kind of posts that people posted. The study was meant to be an experiment in online social interactions and emotional connections.…

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AJOB 2.0: Taking Bioethics to a New Level Fri, 01 Aug 2014 18:29:17 +0000 0