Hot Topics: Genetics
In his recent piece, “The genes we’re dealt,” Erik Parens puts his finger on cause for concern with what he calls social genomics: while progressives can use insights from this new field to justify combating inequality, conservatives can use them to justify the existence of that same inequality. This pessimistic conclusion—which Parens argues convincingly for—follows from a focus on insights at the societal level, that of a whole population. But there are grounds for optimism by focusing instead on potential insights from social genomics derived from local-level comparisons between different environments. Such insights could point to interventions that progressives and conservatives might just be able to agree on.
The post A Narrow Path for Optimism that Social Genomics Can Combat Inequality appeared first on The Hastings Center.Full Article
The international commission on heritable human genome editing (HHGE), formed by the US National Academies of Medicine and Science and the Royal Society of Great Britain, has issued it report. The 224-page report is freely available for reading here, and a summary news report can be accessed here. The upshot: not too fast. The commission’s …Full Article
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This piece appears as an editorial in the August 2020 issue of The American Journal of Bioethics. You can read this piece and others here.
A fundamental concern about applying gene editing to human embryos is how to limit the risk of errors, or “off-target” effects. One makes an edit to change a bad gene’s defect, and presumably prevent the disease the defective gene would cause. But the current methods to do that, although apparently highly selective, might still make …Full Article
by Craig Klugman, Ph.D.
The Good Doctor (Season 3; Episode 16):Who consents when there is more than one personality; New Amsterdam (Season 2; Episode 15): Unanticipated DNA findings; Fudging clinical trials; Chicago Med (Season 5; Episode 15): Killing a death row prisoner, endangering patients
A college student comes into the hospital.…Full Article
In May of 2019 The New Bioethics carried a paper (purchase or subscription required) by Jennifer Gumer of Columbia and Loyola Marymount Universities, summarizing an argument against heritable genome editing (the kind in which an embryo’s genes are edited so that the change will be passed down to the subject’s descendants), based on Belmont principalism. …Full Article
By César Palacios-González @CPalaciosG More than a year after the fallout from He Jiankui’s announcement to the world that he had edited human embryos in order to made them resistant to HIV, the debate on whether we should move ahead with heritable human genome editing has given no signs of slowing down. For example, just a […]Full Article
Some weeks ago, a utilitarian perspective in favor of heritable genome editing was published (purchase or subscription required to read). In it, the author, Kevin Smith of Abertay University in the United Kingdom, begins with a general defense of utilitarianism, the ethical philosophy that what is morally good is what produces the greatest good for …Full Article
In a target article in this Journal in 2018, for which we were two of the co-authors, we discussed the problematic nature of the patenting of foundational (bio)technological processes, in particular the CRISPR-Cas9 (CRISPR) gene-editing technique.…Full Article
by Craig Klugman, Ph.D.
As the legend goes, in the 16th Century, when he was 51 years of age, Ponce de Leon received permission from the King and Queen of Spain to explore the islands north of Puerto Rico to search for the fountain of youth, a fabled spring that would grant eternal life and youth to whomever drank from it or bathed in it.…Full Article
Ethical Advocacy Across the Autism Spectrum: Beyond Partial Representation
Patenting Foundational Technologies: Recent Developments in the CRISPR Patent Struggle
Meaningful Fissures: The Value of Divergent Agendas in Patient Advocacy
From Expectations to Experiences: Consumer Autonomy and Choice in Personal Genomic Testing
Trust and Expectations of Researchers and Public Health Departments for the Use of HIV Molecular Epidemiology
Rational Freedom and Six Mistakes of a Bioconservative
Yesterday’s Child: How Gene Editing for Enhancement Will Produce Obsolescence—and Why It Matters
A Cross-Cultural Neuroethics View on the Language of Disability
Whole-genome sequencing in synthetic biology is advancing, making the possibilities open in new medicines, treating genetic diseases, and sustainable energy. Scientists must keep in mind the ethics of this technology and how it can be misused.Full Article
“A lab experiment aimed at fixing defective DNA in human embryos shows what can go wrong and why leading scientists say it’s too unsafe. In more than half of the cases, the editing caused unintended changes, such as loss of an entire chromosome.” Evident from the analysis of the CRISPR babies made in the years prior, embryo editing has proved to be unstable and not ready for widespread use despite the potentials of editing in solving certain health conditions.Full Article
What is the future of genomic editing? Committees reported on how to proceed with genomic editing, but eventually the process will be up to the individual country. What policy changes would need to happen in the U.S. for this future?Full Article
“Rare parents” are often left charting a world of unknowns. But their persistence has paid off with more advanced treatment options.Full Article
Jack Grehan, who was born with hemophilia, used to inject himself every couple of days with a protein he needs for his blood to clot. But not anymore.Full Article
Over the past few weeks, 23andMe and other genetic testing companies have made headlines for releasing candid statements acknowledging that their field and their products are too white. It’s a problem with which geneticist Tshaka Cunningham is all too familiar.Full Article
At the consumer genetics giant 23andMe, CEO Anne Wojcicki last week issued a remarkable statement calling her product “euro-centric” and saying her company is “part of the problem.”Full Article
The Department of Homeland Security is inching toward implementation of a decades-old law directing it to collect DNA from the undocumented immigrants arrested by its officers.Full Article