Hot Topics: Stem Cells
The international commission on heritable human genome editing (HHGE), formed by the US National Academies of Medicine and Science and the Royal Society of Great Britain, has issued it report. The 224-page report is freely available for reading here, and a summary news report can be accessed here. The upshot: not too fast. The commission’s …Full Article
Henry Ford would be proud. We now have the ability to mass produce humanoids, embryonic cells derived from human embryonic stem cells or induced pluripotent stem cells (the latter can be made from adult cells). These cells are specifically designed by researchers to have some but not all of the necessary elements to be fully …Full Article
Perhaps once a week, I will be asked by a patient about the potential benefits of stem cells for reversing the normal affects of age, particularly with respect to arthritis of the knee joints, hip joints or the degenerative discs in the lumbar spine. I believe one of the reasons for this interest has come …Full Article
A new effort at “somatic” gene editing in China is reported this week. The key summary: “As the researchers report in the New England Journal of Medicine, they transplanted [blood stem] cells that had undergone CRISPR-based editing [of a gene that encodes for a receptor, or “docking station”] into a patient with HIV and acute lymphoblastic …Full Article
Developmental biologist Lewis Wolpert is credited with saying, “It is not birth, marriage, or death, but gastrulation which is truly the most important time in your life.” Gastrulation, simply put, means the embryo develops an axis and distinctly different cell layers. In the human embryo, gastrulation takes place during the third week post-fertilization. Formation of …Full Article
by Craig Klugman, Ph.D.
Move over United States, China is the new research powerhouse. In the last few months, announcements out of China talk about the first live human births from genetically edited embryos; the birth of 5 cloned, genetically edited monkeys, and most recently, announced the development of an artificial intelligencethat is more accurate than human doctors at diagnosing diseases in children.…Full Article
by Jeffrey P. Kahn, Ph.D., M.P.H. and Anna C. Mastroianni, J.D., M.P.H.
National Institutes of Health Director (NIH) Francis S. Collins and Food and Drug Administration Commissioner Scott Gottlieb recently co-authoreda New England Journal of Medicinecommentary suggesting that special oversight of gene transfer research in humans was no longer necessary.…Full Article
A couple of gene-editing news items from this week’s science literature: First, Nature reports that a group in my “back yard,” at the University of California San Diego, has tested gene editing using the CRISPR approach in mice. Recall that CRISPR is an acronym for a particular molecular mechanism, first discovered in bacteria, that is …Full Article
That’s only a slight paraphrase of a news feature article this week in Nature. The clearly-written article is devoid of scientific jargon, with helpful illustrations, open-access online, and readily accessible to the non-specialist. Check it out. Key points include: Scientists who do not find it ethically unacceptable to create and destroy human embryos solely for …Full Article
The Argument from Potentiality in the Embryo Protection Debate: Finally “Depotentialized”?
Response to Open Peer Commentaries on ?Visual Bioethics?
Rescuing Human Embryonic Stem Cell Research: The Blastocyst Transfer Method
What harms do unapproved stem cell interventions bring to patients? There is debate on how these interventions should be managed by the FDA. “Many of these unapproved interventions have led to life-threatening infections, chronic pain, and even death.”Full Article
“The international body representing stem-cell scientists has torn up a decades-old limit on the length of time that scientists should grow human embryos in the lab, giving more leeway to researchers who are studying human development and disease.”Full Article
How can we think about the future of ethical gene therapy research and practice? Past medical practice has impeded these efforts. “Now, a fresh effort to cure Gelsinger’s disease is bearing fruit, in the latest sign of the field’s resurgence.”Full Article
Concern continues to grow over the first human-monkey embryos earlier this month. “The use of primates so closely related to humans raises concerns about unintended consequences, animal welfare and the moral status of hybrid embryos.”Full Article
Recently, scientists have succeeded in growing monkey embryos with human cells. “Combining human cells with closely related primate embryos prompts questions about the status and identity of the resulting hybrids.”Full Article
“The goal is to gain important insights into early human development….. But the research, which was published in two separate papers Wednesday in the journal Nature Portfolio, raises sensitive moral and ethical concerns.”Full Article
“The end of the self-imposed limit could unleash impressive but ethically charged new experiments on extending human development outside the womb.” What are the ethical challenges that would arise from this end to the limit?Full Article
Are brain-like organoids a future in research? “The findings, published in Science on 11 February, could help scientists to understand the genetic pathways that allowed human brains to evolve.”Full Article
Can clumps of cells and disembodied brains be sentient and how would we know if they are? Brain organoids are widely used in labs that study the brain. Some scientists are raising questions on whether this is creation of consciousness and is also allowed.Full Article
“Doctors took cancerous cells from Lacks without her consent, and later created the HeLa cell line, which today supports a multibillion-dollar biotechnology industry.” A recent donation by HHMI is an attempt at reparations for this racial injustice. This donation, the largest received so far, seeks to pay back a fight for recognition of the Lacks family that has been occurring for years. Many see this as the first steps toward true justice.Full Article