Tag: clinical trials

Blog Posts (15)

April 14, 2014

Guidance published on informing study participants about findings with potential health implications

[Wellcome Trust] In the course of a study involving human participants, it is possible that researchers may make a finding that has potential health or reproductive implications for an individual participant. For example, during a brain-imaging study, researchers might identify a brain tumour, or during a genome-wide association study looking for genetic risk factors for […]
April 9, 2014

US jury orders Takeda, Eli Lilly to pay $9 billion in damages over Actos

[FirstWordPharma] A US jury ordered Takeda and Eli Lilly to pay a combined $9 billion in punitive damages after finding that the companies concealed the cancer risks associated with the diabetes therapy Actos (pioglitazone). The jury also awarded compensatory damages to the plaintiff of nearly $1.5 million in the first federal lawsuit related to the […]
February 10, 2012

Is Hope a Culprit in Cancer Clinical Trials?

A recent study conducted by Emory University School of Medicine found that therapeutic misconception is alive and well in Phase I cancer research.…

October 4, 2011

A Duty to Report Dead Ends?

When an investigational agent is being studied by pharma, is there an ethical responsibility to disclose the findings of that research, even if the agent is no longer being studied or being brought to market?…

April 8, 2011

This April in AJOB: Research Subjects as Problems and Mandatory HIV Testing

Today, the April issue of The American Journal of Bioethics is now online.

This month, the journal features two target articles addressing controversial ideas–one in the world of clinical research, the other in the worlds of healthcare and public health.…

September 20, 2010

Are Trials Necessary?

Today's New York Times ran a heartbreaking story by Amy Harmon about two cousins who developed melanoma. One was entered into a cancer clinical trial and received the investigational drug PLX4032. The other was ineligible for the trial, and therefore u...
July 6, 2010

Therapeutic Misconception At Its Worst

The International Society for Stem Cell Research (ISSCR) has created a website that aims purportedly to help patients assess the claims made by stem cell companies and researchers offering cures via stem cell research.…

July 19, 2009

It's Not August! But The August Issue of AJOB is Already Online at Bioethics.net

Now available at bioethics.net is the August issue of The American Journal of Bioethics.

This month’s issue contains articles ranging in topics from organ conscription and whether the US ought to have an opt-out system for organ donation and a number of thought experiments supporting that position by Delaney and Hershenov.…

March 30, 2009

Move Over Victoria's Secret! Stem Cell Trials for Breast Enlargement

Thanks to Wesley Smith’s Secondhand Smoke blog for point out this story from the Times Online, Stem Cells to Grow Bigger Breasts.…

March 3, 2009

March Issue of AJOB is Now Online

Ever wonder what are the obligations by industrialized nations to the countries from which health care workers come? Are these workers free to move or are countries like the US and UK “poaching”?…

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Published Articles (9)

American Journal of Bioethics: Volume 13 Issue 12 - Dec 2013

The SUPPORT Controversy and the Debate Over Research Within the Standard of Care David Magnus

American Journal of Bioethics: Volume 10 Issue 8 - Aug 2010

Translational Research Beyond Approval: A Two-Stage Ethics Review

American Journal of Bioethics: Volume 10 Issue 8 - Aug 2010

The Diverse Ethics of Translational Research

American Journal of Bioethics: Volume 7 Issue 2 - Feb 2007

Money and Distorted Ethical Judgments about Research: Ethical Assessment of the TeGenero TGN1412 Trial

American Journal of Bioethics: Volume 6 Issue 4 - Jul 2006

The Real Problem with Equipoise

American Journal of Bioethics: Volume 6 Issue 5 - Sep 2006

Innovation in Human Research Protection: The AbioCor Artificial Heart Trial

American Journal of Bioethics: Volume 6 Issue 3 - May 2006

Strategies to Minimize Risks and Exploitation in Phase One Trials on Healthy Subjects

American Journal of Bioethics: Volume 5 Issue 3 - May 2005

U.S. Military Sponsored Vaccine Trials and La Resistance in Nepal

American Journal of Bioethics: Volume 4 Issue 2 - Jun 2004

When ?Minimal Risk? Research Yields Clinically-Significant Data, Maybe the Risks Aren?t So Minimal

News (25)

August 14, 2013 6:27 pm

Safety First? How the Current Drug Approval System Lets Some Patients Down

Licensed drugs have to go through rigorous trials. Even if an unlicensed drug works in some way, it might kill you in another way or cause problems.

February 22, 2013 12:41 pm

Families Push for New Ways to Research Rare Diseases (WSJ)

Parents with children who have rare and debilitating diseases are pushing to change how researchers develop medicines to treat the conditions.  The parents want different scientists researching the diseases to share data about the patients so the children won’t need to participate in so many studies.

January 28, 2013 1:33 pm

Lumpectomy Saves Lives in Early Breast Cancer (MedPage Today)

In real-world practice, women with early-stage breast cancer were more likely to survive if they had a lumpectomy rather than mastectomy, a population-based registry study found.

January 23, 2013 4:32 pm

Bird Flu Research to Resume After Safety Debate (New York Times)

Experiments with a deadly flu virus, suspended last year after a fierce global debate over safety, will start up again in some laboratories, probably within the next few weeks, scientists say.

December 12, 2012 2:02 pm

Coffee May Lower Risk of Dying From Oral Cancers (WebMD)

Heavy coffee drinkers — those who drink more than four cups a day — may cut their risk of dying from cancers of the mouth and throat by nearly half, according to new research.

December 11, 2012 2:04 pm

Obesity, diabetes are robbing people of sight (USA Today)

The nation’s twin epidemics of obesity and diabetes are robbing more Americans of their sight.  The percentage of American adults suffering from uncorrectable vision loss spiked 21% in only about six years, rising to nearly 1.7% of the population.

December 7, 2012 4:33 pm

Beer May Have Anti-Virus Properties According to a New Study (Huffington Post)

According to a new study funded by Japanese beer company Sapporo Breweries, a “key ingredient” found in the world’s most popular alcoholic beverage may very well help stave off winter sniffles.

December 5, 2012 7:13 pm

Bigger Role Seen for Breast Cancer Drug (NYT)

The widely prescribed drug tamoxifen already plays a major role in reducing the risk of death from breast cancer. But a new study suggests that women should be taking the drug for twice as long could upend the standard that has been in place for about 15 years.

November 29, 2012 6:36 pm

Whooping Cough Vaccine Less Effective Over Time: Study (HealthDay)

The 2010 outbreak of whooping cough (pertussis) in California, which sickened more than 9,000 people and left 10 infants dead, prompted an examination of the current vaccine’s effectiveness. That study concluded that the vaccine is effective but loses power over the years, leaving children 7 to 10 years old particularly susceptible.

November 29, 2012 6:26 pm

Recession Big Factor as Birthrate Falls (Wall Street Journal)

The annual number of births per 1,000 women ages 15 to 44 dropped 8% in the U.S. from 2007 to 2010 to 64 births per 1,000, according to a report released Thursday by the nonpartisan Pew center. The U.S. birthrate peaked during the baby boom, at 122.7 in 1957.

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